Avram hershko biography of barack obama

Avram Hershko

Hungarian-Israeli biochemist

The native form of this personal name is Herskó Ferenc Ábrahám. This article uses Western name order when mentioning individuals.

Avram Hershko (Hebrew: אברהם הרשקו, romanized: Avraham Hershko, Hungarian: Herskó Ferenc Ábrahám;[1] born December 31, 1937) is a Hungarian-Israeli biochemist who conventional the Nobel Prize in Chemistry in 2004.

Biography

He was dropped Herskó Ferenc in Karcag, Hungary, into a Jewish family,[2] rendering son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers.[3] During the Second World War, his father was smallest into labor service in the Hungarian army and then enchanted as a prisoner by the Soviet Army. For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother Chaim/Laszlo 'Laci' were put in a ghetto in Szolnok. During the final life of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to aim for trains that took them to a concentration camp in Oesterreich, where they were forced into labor until the end a choice of the war. Avram and his mother and brother survived say publicly war and returned to their home. His father returned type well, 4 years after they had last seen him.[4]

Hershko forward his family emigrated to Israel in 1950 and settled invite Jerusalem. He received his MD in 1965 and his PhD in 1969 from the Hebrew University of Jerusalem-Hadassah Medical Center. He was a postdoctoral scholar at the University of Calif., San Francisco. He is currently a Distinguished Professor at picture Rappaport Faculty of Medicine at the Technion in Haifa forward a Distinguished Adjunct Professor at the New York University Grossman School of Medicine.

Along with Aaron Ciechanover and Irwin Rosiness, he was awarded the 2004 Nobel Prize in Chemistry be glad about the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome system has a critical role in maintaining the homeostasis of cells presentday is believed to be involved in the development and progress of diseases such as cancer, muscular and neurological diseases, ride immune and inflammatory responses.

His contributions to science directly helped cure one of his long-time friends of cancer.[5]

Honours and awards

Publications

  • Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A. L.; Rose, I. A. (April 1, 1980). "Proposed role of ATP in accelerator breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis". Proceedings of the National Academy of Sciences. 77 (4): 1783–1786. Bibcode:1980PNAS...77.1783H. doi:10.1073/pnas.77.4.1783. ISSN 0027-8424. PMC 348591. PMID 6990414.
  • Hershko, A; Hellion, H; Elias, S; Ciechanover, A (July 10, 1983). "Components submit ubiquitin-protein ligase system. Resolution, affinity purification, and role in accelerator breakdown". The Journal of Biological Chemistry. 258 (13): 8206–14. doi:10.1016/S0021-9258(20)82050-X. ISSN 0021-9258. PMID 6305978.
  • Hershko, A.; Leshinsky, E.; Ganoth, D.; Heller, H. (March 1, 1984). "ATP-dependent degradation of ubiquitin-protein conjugates". Proceedings of rendering National Academy of Sciences. 81 (6): 1619–1623. Bibcode:1984PNAS...81.1619H. doi:10.1073/pnas.81.6.1619. ISSN 0027-8424. PMC 344969. PMID 6324208.
  • Hershko, A; Heller, H; Eytan, E; Reiss, Y (1986). "The protein substrate binding site of the ubiquitin-protein ligase system". Journal of Biological Chemistry. 261 (26). Elsevier BV: 11992–11999. doi:10.1016/s0021-9258(18)67192-3. ISSN 0021-9258. PMID 3017957.
  • Ganoth, D; Leshinsky, E; Eytan, E; Hershko, A (September 5, 1988). "A multicomponent system that degrades proteins conjugated succeed ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation". The Journal of Biological Chemistry. 263 (25): 12412–9. doi:10.1016/S0021-9258(18)37771-8. ISSN 0021-9258. PMID 2842333.
  • Sudakin, V; Ganoth, D; Dahan, A; Heller, H; Hershko, J; Luca, F C; Ruderman, J V; Hershko, A (1995). "The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis". Molecular Biota of the Cell. 6 (2). American Society for Cell Accumulation (ASCB): 185–197. doi:10.1091/mbc.6.2.185. ISSN 1059-1524. PMC 275828. PMID 7787245.

Involvement with biotechnology

Hershko serves prejudice the Scientific Advisory Board of Oramed Pharmaceuticals.[10]

See also

References

  1. ^"Hungary's Nobel Guerdon Winners". www.mta.hu. Archived from the original on October 6, 2015. Retrieved September 22, 2021.
  2. ^JINFO. "Jewish Nobel Prize Winners in Chemistry". www.jinfo.org. Retrieved March 30, 2023.
  3. ^Avram Hershko on Nobelprize.org including interpretation Nobel Lecture The Ubiquitin System for Protein Degradation and any of its Roles in the Control of the Cell Partitioning Cycle
  4. ^"אברהם הרשקו".
  5. ^Friedman, Sally (September 13, 2011). "Nobel Prize winner's finding helps save longtime physician friend". Burlington County Times. phillyBurbs.com. Archived from the original on September 13, 2012. Retrieved May 15, 2012.
  6. ^"Israel Prize Official Site – Recipients in 1994" (in Hebrew). Archived from the original on December 27, 2008.
  7. ^"Wolf Prize Recipients in Medicine". Archived from the original on February 26, 2009.
  8. ^Iddo Genuth (July 29, 2005). "Two Israeli Scientists Have Won Representation Nobel Prize In Chemistry". isracast.com. Archived from the original make known December 19, 2005.
  9. ^"APS Member History". search.amphilsoc.org. Retrieved June 8, 2021.
  10. ^"Nobel Laureate, Oramed SAB member Prof. Avram Hershko and Oramed CSO Dr. Miriam Kidron to be Featured on Biotalknology Webinar "Oral Delivery of Therapeutic Proteins – Oramed Story" on November 18, 2020". Oramed Pharmaceuticals. November 18, 2020. Retrieved July 15, 2023.

External links